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S1PR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZTI
Identifiers
Aliases	S1PR2, AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2, DFNB68, sphingosine-1-phosphate receptor 2
External IDs	OMIM: 605111; MGI: 99569; HomoloGene: 3118; GeneCards: S1PR2; OMA:S1PR2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 10,221,433 bp End 10,231,331 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 A3|9 7.68 cM Start 20,873,657 bp End 20,888,077 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle vena cava stromal cell of endometrium parotid gland placenta upper lobe of left lung sperm left uterine tube gastric mucosa canal of the cervix Top expressed in decidua efferent ductule vas deferens dermis left lung lobe calvaria otic vesicle abdominal wall tracheobronchial tree lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity lipid binding G protein-coupled receptor binding G protein-coupled receptor activity integrin binding protein binding sphingosine-1-phosphate receptor activity Cellular component membrane integral component of membrane plasma membrane Biological process actin cytoskeleton reorganization positive regulation of establishment of endothelial barrier positive regulation of cell population proliferation G protein-coupled receptor signaling pathway filopodium assembly signal transduction sphingosine-1-phosphate receptor signaling pathway positive regulation of peptidyl-threonine phosphorylation negative regulation of excitatory postsynaptic potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9294 14739 Ensembl ENSG00000267534 ENSMUSG00000043895 UniProt O95136 P52592 RefSeq (mRNA) NM_004230 NM_010333 RefSeq (protein) NP_004221 NP_034463 Location (UCSC) Chr 19: 10.22 – 10.23 Mb Chr 9: 20.87 – 20.89 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P₂, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).

Function

This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation. It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor. S1PR2 is expressed in neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system.

Evolution

Paralogues

• S1PR1
• S1PR3
• S1PR5
• S1PR4
• LPAR2
• LPAR1
• LPAR3
• CNR1
• GPR6
• MC3R
• GPR12
• GPR3
• MC4R
• MC1R
• CNR2
• MC5R
• MC2R
• GPR119

See also

• Lysophospholipid receptor

References

1. ^ GRCh38: Ensembl release 89: ENSG00000267534 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000043895 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: S1PR2, sphingosine-1-phosphate receptor 2".
6. Kempf A, Tews B, Arzt ME, Weinmann O, Obermair FJ, Pernet V, Zagrebelsky M, Delekate A, Iobbi C, Zemmar A, Ristic Z, Gullo M, Spies P, Dodd D, Gygax D, Korte M, Schwab ME, Schiavo G (14 January 2014). "The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity". PLOS Biology. 12 (1): e1001763. doi:10.1371/journal.pbio.1001763. PMC 3891622. PMID 24453941.
7. Rust R, Grönnert L, Gantner C, Enzler A, Mulders G, Weber RZ, Siewert A, Limasale YDP, Meinhardt A, Maurer MA, Sartori AM, Hofer AS, Werner C, Schwab ME (9 July 2019). "Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke". Proceedings of the National Academy of Sciences. 116 (28): 14270–14279. Bibcode:2019PNAS..11614270R. doi:10.1073/pnas.1905309116. PMC 6628809. PMID 31235580.
8. Rust R, Grönnert L, Weber RZ, Mulders G, Schwab ME (September 2019). "Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair". Trends in Neurosciences. 42 (9): 644–656. doi:10.1016/j.tins.2019.05.006. PMID 31285047. S2CID 195834057.
9. "GeneCards®: The Human Gene Database".

Further reading

• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905 (1): 54–60. Bibcode:2000NYASA.905...54S. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441. S2CID 9257870.
• Takuwa Y (2002). "". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348.
• MacLennan AJ, Browe CS, Gaskin AA, et al. (1994). "Cloning and characterization of a putative G-protein coupled receptor potentially involved in development". Mol. Cell. Neurosci. 5 (3): 201–9. doi:10.1006/mcne.1994.1024. PMID 8087418. S2CID 34088289.
• Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9". Biochem. Biophys. Res. Commun. 227 (2): 608–14. doi:10.1006/bbrc.1996.1553. PMID 8878560.
• Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218". J. Biol. Chem. 274 (8): 4626–32. doi:10.1074/jbc.274.8.4626. PMID 9988698.
• Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399.
• Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
• An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5". J. Biol. Chem. 275 (1): 288–96. doi:10.1074/jbc.275.1.288. PMID 10617617.
• Himmel HM, Meyer Zu Heringdorf D, Graf E, et al. (2000). "Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes". Mol. Pharmacol. 58 (2): 449–54. doi:10.1124/mol.58.2.449. PMID 10908314. S2CID 7014378.
• Hla T (April 2001). "Sphingosine 1-phosphate receptors". Prostaglandins. 64 (1–4): 135–142. doi:10.1016/s0090-6980(01)00109-5. PMID 11331101.
• Mazurais D, Robert P, Gout B, et al. (2002). "Cell type-specific localization of human cardiac S1P receptors". J. Histochem. Cytochem. 50 (5): 661–70. doi:10.1177/002215540205000507. PMID 11967277. S2CID 35685259.
• Osada M, Yatomi Y, Ohmori T, et al. (2003). "Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist". Biochem. Biophys. Res. Commun. 299 (3): 483–7. doi:10.1016/S0006-291X(02)02671-2. PMID 12445827.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vogler R, Sauer B, Kim DS, et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
• Kaneider NC, Lindner J, Feistritzer C, et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor". FASEB J. 18 (11): 1309–11. doi:10.1096/fj.03-1050fje. PMID 15208267. S2CID 22590944.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sanchez T, Thangada S, Wu MT, et al. (2005). "PTEN as an effector in the signaling of antimigratory G protein-coupled receptor". Proc. Natl. Acad. Sci. U.S.A. 102 (12): 4312–7. Bibcode:2005PNAS..102.4312S. doi:10.1073/pnas.0409784102. PMC 555509. PMID 15764699.
• Sanchez T, Skoura A, Wu MT, et al. (2007). "Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN". Arterioscler. Thromb. Vasc. Biol. 27 (6): 1312–8. doi:10.1161/ATVBAHA.107.143735. PMID 17431187.

External links

• "Lysophospholipid Receptors: S₁P₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
• Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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