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LPAR5
Identifiers
Aliases	LPAR5, GPR92, GPR93, KPG_010, LPA5, lysophosphatidic acid receptor 5
External IDs	OMIM: 606926; MGI: 2685918; HomoloGene: 10696; GeneCards: LPAR5; OMA:LPAR5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 6,618,835 bp End 6,635,960 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F2 Start 125,044,883 bp End 125,059,435 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium mucosa of ileum oral cavity mucosa of colon mucosa of sigmoid colon mucosa of transverse colon palpebral conjunctiva jejunal mucosa amniotic fluid endothelial cell Top expressed in jejunum colon esophagus ileum duodenum lip embryo embryo spleen stomach More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity molecular function Cellular component integral component of membrane plasma membrane membrane cellular component Biological process signal transduction G protein-coupled receptor signaling pathway biological process positive regulation of CREB transcription factor activity behavioral response to pain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57121 381810 Ensembl ENSG00000184574 ENSMUSG00000067714 UniProt Q9H1C0 Q149R9 RefSeq (mRNA) NM_020400 NM_001142961 NM_001163268 NM_001163269 RefSeq (protein) NP_001136433 NP_065133 NP_001156740 NP_001156741 Location (UCSC) Chr 12: 6.62 – 6.64 Mb Chr 6: 125.04 – 125.06 Mb PubMed search
Wikidata
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Lysophosphatidic acid receptor 5 also known as LPA₅ is a protein that in humans is encoded by the LPAR5 gene. LPA₅ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

See also

• Lysophospholipid receptor

References

1. ^ GRCh38: Ensembl release 89: ENSG00000184574 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000067714 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nature Genetics. 26 (3): 345–348. November 2000. doi:10.1038/81664. PMID 11062477. S2CID 38870810.
6. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, et al. (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
7. Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (August 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5". The Journal of Biological Chemistry. 281 (33): 23589–23597. doi:10.1074/jbc.M603670200. PMID 16774927.
8. Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, et al. (August 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". The Journal of Pharmacology and Experimental Therapeutics. 318 (2): 619–628. doi:10.1124/jpet.105.098848. PMID 16651401. S2CID 5989815.
9. "Entrez Gene: GPR92 G protein-coupled receptor 92".
10. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, et al. (January 2010). "LPA receptors: subtypes and biological actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

Further reading

• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.

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