GPR174 - Misplaced Pages

Protein-coding gene in humans

GPR174

Identifiers

GPR174, GPCR17, LYPSR3, FKSG79, G protein-coupled receptor 174

External IDs

OMIM: 300903; MGI: 2685222; HomoloGene: 13059; GeneCards: GPR174; OMA:GPR174 - orthologs

Gene location (Human)

Chr.	X chromosome (human)

Band	Xq21.1	Start	79,144,688 bp
Band	Xq21.1	End	79,175,318 bp

Gene location (Mouse)

Chr.	X chromosome (mouse)

Band	X\|X D	Start	106,299,484 bp
Band	X\|X D	End	106,340,375 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

thymus

mucosa of ileum

lymph node

granulocyte

appendix

epithelium of nasopharynx

epithelium of colon

spleen

superficial temporal artery

blood

Top expressed in

spleen

mesenteric lymph nodes

blood

thymus

lumbar spinal ganglion

subcutaneous adipose tissue

lumbar subsegment of spinal cord

granulocyte

white adipose tissue

dermis

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity bioactive lipid receptor activity
Cellular component	integral component of membrane plasma membrane membrane integral component of plasma membrane
Biological process	signal transduction G protein-coupled receptor signaling pathway positive regulation of Rho protein signal transduction T cell homeostasis positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


84636


213439

Ensembl


ENSG00000147138


ENSMUSG00000073008

UniProt


Q9BXC1


Q3U507

RefSeq (mRNA)


NM_032553


NM_001033251 NM_001177781 NM_001177782 NM_001358747

RefSeq (protein)


NP_115942


NP_001028423 NP_001171252 NP_001171253 NP_001345676

Location (UCSC)

Chr X: 79.14 – 79.18 Mb

Chr X: 106.3 – 106.34 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene. The receptor has been reported to bind to lysophosphatidylserine.

References

^ GRCh38: Ensembl release 89: ENSG00000147138 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000073008 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: GPR174 G protein-coupled receptor 174".
Liu G, Li X, Wang Y, Zhang X, Gong W (2023). "Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174". PLOS Biol. 21 (12): e3002387. doi:10.1371/journal.pbio.3002387. PMC 10721165. PMID 38048360.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y; et al. (2023). "Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling". Nat Commun. 14 (1): 5901. doi:10.1038/s41467-023-41654-3. PMC 10516915. PMID 37737235.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. Bibcode:2002FEBSL.520...97T. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.

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Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled & Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

Categories:

References

Further reading