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GPR12
Identifiers
Aliases	GPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDs	OMIM: 600752; MGI: 101909; HomoloGene: 3868; GeneCards: GPR12; OMA:GPR12 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q12.13 Start 26,755,200 bp End 26,760,786 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G3 Start 146,519,208 bp End 146,522,049 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence cerebellar hemisphere right hemisphere of cerebellum nucleus accumbens caudate nucleus prefrontal cortex putamen Brodmann area 9 cingulate gyrus anterior cingulate cortex Top expressed in perirhinal cortex entorhinal cortex CA3 field primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell hippocampus proper Region I of hippocampus proper dorsal striatum nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity phosphatidylcholine binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway cellular calcium ion homeostasis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2835 14738 Ensembl ENSG00000132975 ENSMUSG00000041468 UniProt P47775 P35412 RefSeq (mRNA) NM_005288 NM_001010941 NM_008151 NM_001359055 NM_001359056 NM_001359057 NM_001359058 RefSeq (protein) NP_005279 NP_001010941 NP_032177 NP_001345984 NP_001345985 NP_001345986 NP_001345987 Location (UCSC) Chr 13: 26.76 – 26.76 Mb Chr 5: 146.52 – 146.52 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.

Ligands

Inverse agonists

• Cannabidiol

Evolution

Paralogues

Source:

• GPR6
• GPR3
• S1PR5
• CNR1
• CNR2
• MC4R
• S1PR1
• MC3R
• MC2R
• S1PR2
• MC1R
• S1PR3
• LPAR2
• MC5R
• LPAR1
• S1PR4
• LPAR3
• GPR119

References

1. ^ GRCh38: Ensembl release 89: ENSG00000132975 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000041468 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Letters. 336 (2): 317–22. doi:10.1016/0014-5793(93)80828-I. PMID 8262253. S2CID 31345248.
6. Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
7. "Entrez Gene: GPR12 G protein-coupled receptor 12".
8. Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–66. doi:10.1016/j.bbrc.2006.07.090. PMID 16887097.
9. Brown KJ, Laun AS, Song ZH (November 2017). "Cannabidiol, a novel inverse agonist for GPR12". Biochemical and Biophysical Research Communications. 493 (1): 451–454. doi:10.1016/j.bbrc.2017.09.001. PMC 5849771. PMID 28888984.
10. "GeneCards®: The Human Gene Database".

Further reading

• Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592. S2CID 45156405.

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