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CELSR3
Identifiers
Aliases	CELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1, ADGRC3, cadherin EGF LAG seven-pass G-type receptor 3
External IDs	OMIM: 604264; MGI: 1858236; HomoloGene: 1077; GeneCards: CELSR3; OMA:CELSR3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 48,636,463 bp End 48,662,886 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F2 Start 108,703,519 bp End 108,730,168 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum ganglionic eminence Pituitary Gland paraflocculus of cerebellum Brodmann area 10 cerebellar vermis anterior pituitary right frontal lobe postcentral gyrus Region I of hippocampus proper Top expressed in cerebellar cortex Hypothalamus olfactory bulb ganglionic eminence primary visual cortex superior frontal gyrus striatum of neuraxis granulocyte layer of retina neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding G protein-coupled receptor activity signal transducer activity protein binding transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane Biological process regulation of protein phosphorylation dopaminergic neuron axon guidance G protein-coupled receptor signaling pathway serotonergic neuron axon guidance neuron migration regulation of protein localization multicellular organism development Wnt signaling pathway, planar cell polarity pathway cell surface receptor signaling pathway cell adhesion axonal fasciculation signal transduction homophilic cell adhesion via plasma membrane adhesion molecules planar cell polarity pathway involved in axon guidance cilium assembly cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1951 107934 Ensembl ENSG00000008300 ENSMUSG00000023473 UniProt Q9NYQ7 Q91ZI0 RefSeq (mRNA) NM_001407 NM_080437 NM_001359572 NM_001359573 RefSeq (protein) NP_001398 NP_536685 NP_001346501 NP_001346502 Location (UCSC) Chr 3: 48.64 – 48.66 Mb Chr 9: 108.7 – 108.73 Mb PubMed search
Wikidata
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Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.

See also

• Flamingo (protein)

References

1. ^ GRCh38: Ensembl release 89: ENSG00000008300 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000023473 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
6. ^ "Entrez Gene: CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
• Formstone CJ, Barclay J, Rees M, Little PF (2000). "Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9". Mamm. Genome. 11 (5): 392–4. doi:10.1007/s003350010073. PMID 10790539. S2CID 21333332.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

External links

• Human CELSR3 genome location and CELSR3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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