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GPR68
Identifiers
Aliases	GPR68, GPR12A, OGR1, G protein-coupled receptor 68, AI2A6
External IDs	OMIM: 601404; MGI: 2441763; HomoloGene: 2603; GeneCards: GPR68; OMA:GPR68 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.11 Start 91,232,532 bp End 91,253,925 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 E Start 100,842,941 bp End 100,874,457 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii granulocyte gingival epithelium testicle cardia pylorus buccal mucosa cell saphenous vein Pituitary Gland human penis Top expressed in zygote oocyte primary oocyte secondary oocyte mesenteric lymph nodes lumbar subsegment of spinal cord dentate gyrus of hippocampal formation granule cell cerebellar cortex hippocampus proper ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway negative regulation of monocyte differentiation positive regulation of insulin secretion involved in cellular response to glucose stimulus cellular response to pH inflammatory response positive regulation of osteoclast development signal transduction positive regulation of insulin secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8111 238377 Ensembl ENSG00000119714 ENSMUSG00000047415 UniProt Q15743 Q8BFQ3 RefSeq (mRNA) NM_001177676 NM_003485 NM_001348437 NM_001177673 NM_001177674 NM_175493 RefSeq (protein) NP_001171147 NP_003476 NP_001335366 NP_001171144 NP_001171145 NP_780702 NP_001390243 Location (UCSC) Chr 14: 91.23 – 91.25 Mb Chr 12: 100.84 – 100.87 Mb PubMed search
Wikidata
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Ovarian cancer G-protein coupled receptor 1 is a protein that in humans is encoded by the GPR68 gene.

See also

• Proton-sensing G protein-coupled receptors

References

1. ^ GRCh38: Ensembl release 89: ENSG00000119714 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000047415 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu Y, Casey G (Sep 1996). "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14". Genomics. 35 (2): 397–402. doi:10.1006/geno.1996.0377. PMID 8661159.
6. "Entrez Gene: GPR68 G protein-coupled receptor 68".

Further reading

• Xu Y (2002). "Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction". Biochim. Biophys. Acta. 1582 (1–3): 81–8. doi:10.1016/S1388-1981(02)00140-3. PMID 12069813.
• An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue". FEBS Lett. 375 (1–2): 121–4. doi:10.1016/0014-5793(95)01196-L. PMID 7498459. S2CID 9845527.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ludwig MG, Vanek M, Guerini D, et al. (2003). "Proton-sensing G-protein-coupled receptors". Nature. 425 (6953): 93–8. Bibcode:2003Natur.425...93L. doi:10.1038/nature01905. PMID 12955148. S2CID 4395698.
• Bektas M, Barak LS, Jolly PS, et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner". Biochemistry. 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. Bibcode:2005PNAS..102.1632R. doi:10.1073/pnas.0409415102. PMC 545089. PMID 15665078.
• Tomura H, Wang JQ, Komachi M, et al. (2005). "Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells". J. Biol. Chem. 280 (41): 34458–64. doi:10.1074/jbc.M505287200. PMID 16087674.
• Singh LS, Berk M, Oates R, et al. (2007). "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer". J. Natl. Cancer Inst. 99 (17): 1313–27. doi:10.1093/jnci/djm107. hdl:10536/DRO/DU:30094039. PMID 17728215.

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