Misplaced Pages

Cytochrome P450, family 107, also known as CYP107, is a cytochrome P450 monooxygenase family in bacteria, found to be conserved and highly populated in Streptomyces and Bacillus species. The first gene identified in this family is Cytochrome P450 eryF (CYP107A1) from Saccharopolyspora erythraea. Many enzymes of this family are involved in the synthesis of macrolide antibiotics. The members of this family are widely distributed in Alphaproteobacteria, cyanobacterial, Mycobacterium, Bacillota, and Streptomyces species, which may be due to horizontal gene transfer driven by selection pressure.

References

1. ^ Nebert, DW; Nelson, DR; Coon, MJ; Estabrook, RW; Feyereisen, R; Fujii-Kuriyama, Y; Gonzalez, FJ; Guengerich, FP; Gunsalus, IC; Johnson, EF (January 1991). "The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature". DNA and Cell Biology. 10 (1): 1–14. doi:10.1089/dna.1991.10.1. PMID 1991046.
2. ^ Padayachee, T; Lamb, DC; Nelson, DR; Syed, K (1 December 2023). "Structure-Function Analysis of the Biotechnologically Important Cytochrome P450 107 (CYP107) Enzyme Family". Biomolecules. 13 (12): 1733. doi:10.3390/biom13121733. PMC 10741444. PMID 38136604.
3. Mnguni, FC; Padayachee, T; Chen, W; Gront, D; Yu, JH; Nelson, DR; Syed, K (7 July 2020). "More P450s Are Involved in Secondary Metabolite Biosynthesis in Streptomyces Compared to Bacillus, Cyanobacteria, and Mycobacterium". International Journal of Molecular Sciences. 21 (13): 4814. doi:10.3390/ijms21134814. PMC 7369989. PMID 32646068.
4. Weber, JM; Leung, JO; Swanson, SJ; Idler, KB; McAlpine, JB (5 April 1991). "An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea". Science. 252 (5002): 114–7. Bibcode:1991Sci...252..114W. doi:10.1126/science.2011746. PMID 2011746.
5. Kim, V; Lim, YR; Lee, I; Lee, JH; Han, S; Pham, TV; Kim, H; Lee, R; Kang, LW; Kim, D (15 October 2020). "Structural insights into CYP107G1 from rapamycin-producing Streptomyces rapamycinicus". Archives of Biochemistry and Biophysics. 692: 108544. doi:10.1016/j.abb.2020.108544. PMID 32822639. S2CID 221236896.
6. Nzuza, N; Padayachee, T; Syed, PR; Kryś, JD; Chen, W; Gront, D; Nelson, DR; Syed, K (2021-05-24). "Ancient Bacterial Class Alphaproteobacteria Cytochrome P450 Monooxygenases Can Be Found in Other Bacterial Species". International Journal of Molecular Sciences. 22 (11): 5542. doi:10.3390/ijms22115542. PMC 8197338. PMID 34073951.

This genetics article is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Cytochrome P450
• Protein families
• Genetics stubs