| Ent-isokaurene C2-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.143 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Ent-isokaurene C2-hydroxylase (EC 1.14.13.143, CYP71Z6) is an enzyme with systematic name ent-isokaurene,NADPH:oxygen oxidoreductase (hydroxylating). This enzyme catalyses the following chemical reaction
- ent-isokaurene + O2 + NADPH + H ent-2alpha-hydroxyisokaurene + H2O + NADP
ent-2alpha-hydroxyisokaurene + H2O + NADPEnt-isokaurene C2-hydroxylase performs the initial step in the conversion of ent-isokaurene to the antibacterial oryzalides in rice, Oryza sativa.
References
- Wu Y, Hillwig ML, Wang Q, Peters RJ (November 2011). "Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7". FEBS Letters. 585 (21): 3446–51. doi:10.1016/j.febslet.2011.09.038. PMC 3227696. PMID 21985968.
External links
- Ent-isokaurene+C2-hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
| Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14) | |
|---|---|
| 1.14.11: 2-oxoglutarate | |
| 1.14.13: NADH or NADPH | |
| 1.14.14: reduced flavin or flavoprotein | |
| 1.14.15: reduced iron–sulfur protein | |
| 1.14.16: reduced pteridine (BH4 dependent) | |
| 1.14.17: reduced ascorbate | |
| 1.14.18-19: other | |
| 1.14.99 - miscellaneous | |
| Enzymes | |
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| Activity | |
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| Classification | |
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