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MK-9470

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MK-9470
-MK-9470
Names
Preferred IUPAC name N-butan-2-yl]-2-methyl-2-(5-methylpyridin-2-yl)oxypropanamide
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C29H32FN3O3/c1-20-8-13-27(32-19-20)36-29(3,4)28(34)33-21(2)26(24-7-5-6-23(16-24)18-31)17-22-9-11-25(12-10-22)35-15-14-30/h5-13,16,19,21,26H,14-15,17H2,1-4H3,(H,33,34)/t21-,26+/m0/s1Key: JWBGLSNXGRDLKH-HFZDXXHNBD
  • : InChI=1S/C29H32FN3O3/c1-20-8-13-27(32-19-20)36-29(3,4)28(34)33-21(2)26(24-7-5-6-23(16-24)18-31)17-22-9-11-25(12-10-22)35-15-14-30/h5-13,16,19,21,26H,14-15,17H2,1-4H3,(H,33,34)/t21-,26+/m0/s1/i30-1Key: XIYPJXKEMLKFMD-MSNFMOCCSA-N
SMILES
  • CC1=CN=C(C=C1)OC(C)(C)C(=O)N(C)(CC2=CC=C(C=C2)OCCF)C3=CC=CC(=C3)C#N
  • : (CC1=CC=C(OCC)C=C1)((NC(C(OC2=CC=C(C)C=N2)(C)C)=O)C)C3=CC(C#N)=CC=C3
Properties
Chemical formula C29H32FN3O3
Molar mass 489.591 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

MK-9470 is a synthetic compound which binds to the CB1 cannabinoid receptor and functions as an inverse agonist. The F-labeled version, -MK-9470, is used in research as a positron emission tomography (PET) tracer for brain imaging of the CB1 receptor.

References

  1. Burns HD, Van Laere K, Sanabria-Bohórquez S, Hamill TG, Bormans G, Eng WS, et al. (June 2007). "[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor". Proceedings of the National Academy of Sciences of the United States of America. 104 (23): 9800–9805. Bibcode:2007PNAS..104.9800B. doi:10.1073/pnas.0703472104. PMC 1877985. PMID 17535893.
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