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TL-1238

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Chemical compound
TL-1238
Names
Preferred IUPAC name 3--N,N-diethyl-N-methylanilinium iodide
Other names Substance 3393
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C14H23N2O2.HI/c1-6-16(5,7-2)12-9-8-10-13(11-12)18-14(17)15(3)4;/h8-11H,6-7H2,1-5H3;1H/q+1;/p-1Key: HBVVWBFVSLUJNP-UHFFFAOYSA-M
SMILES
  • CC(C)(CC)c1cccc(c1)OC(=O)N(C)C.
Properties
Chemical formula C14H23IN2O2
Molar mass 378.254 g·mol
Hazards
Occupational safety and health (OHS/OSH):
Main hazards Extremely toxic
Lethal dose or concentration (LD, LC):
LD50 (median dose) 175 μg/kg (subcutaneous, mice)
89 μg/kg (intravenous, mice)
60 μg/kg (intravenous, mice)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

TL-1238 (Substance 3393) is an extremely potent carbamate acetylcholinesterase inhibitor. It has been shown to be more potent than the parent compound neostigmine.

See also

References

  1. ^ Chemical Warfare Agents, and Related Chemical Problems. Parts I-II. 1958.
  2. ^ Bülbring, E; Chou, TC (March 1947). "The relative activity of prostigmine homologues and other substances as antagonists to tubocurarine". British Journal of Pharmacology and Chemotherapy. 2 (1): 8–22. doi:10.1111/j.1476-5381.1947.tb00316.x. PMC 1509759. PMID 19108106.
  3. BLASCHKO, H; BULBRING, E; CHOU, TC (March 1949). "Tubocurarine antagonism and inhibition of cholinesterases". British Journal of Pharmacology and Chemotherapy. 4 (1): 29–32. doi:10.1111/j.1476-5381.1949.tb00512.x. PMC 1509899. PMID 18113150.
Acetylcholine metabolism and transport modulators
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
Release
(modulators)
Inhibitors
Enhancers
See also
Receptor/signaling modulators
Muscarinic acetylcholine receptor modulators
Nicotinic acetylcholine receptor modulators
Blood agents
Blister agents
Arsenicals
  • Ethyldichloroarsine (ED)
  • Methyldichloroarsine (MD)
  • Phenyldichloroarsine (PD)
  • Lewisite (L)
  • Lewisite 2 (L2)
  • Lewisite 3 (L3)
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    Nerve agents
    G-agents
    V-agents
    GV agents
    Novichok agents
    Carbamates
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    Precursors
    Neurotoxins
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    choking agents
    Vomiting agents
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    agents
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