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HIVEP3
Identifiers
Aliases	HIVEP3, Hivep3, 2900056N03Rik, A130075N07, AI848000, E030045D18Rik, KBP-1, KBP1, Rc, Schnurri-3, Shn3, Zas3, ZNF40C, human immunodeficiency virus type I enhancer binding protein 3, Kappa Recognition Component (Krc), KRC, HIVEP zinc finger 3
External IDs	OMIM: 606649; MGI: 106589; HomoloGene: 7803; GeneCards: HIVEP3; OMA:HIVEP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 41,506,365 bp End 42,035,925 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.1 Start 119,590,981 bp End 119,995,242 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell endothelial cell Brodmann area 23 cartilage tissue parietal pleura primary visual cortex granulocyte middle temporal gyrus entorhinal cortex germinal epithelium Top expressed in gastrula medial geniculate nucleus Rostral migratory stream subiculum medial dorsal nucleus lateral geniculate nucleus substantia nigra trigeminal ganglion anterior amygdaloid area submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process multicellular organism development skeletal muscle cell differentiation positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II signal transduction transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59269 16656 Ensembl ENSG00000127124 ENSMUSG00000028634 UniProt Q5T1R4 A2A884 RefSeq (mRNA) NM_001127714 NM_024503 NM_010657 RefSeq (protein) NP_001121186 NP_078779 NP_034787 Location (UCSC) Chr 1: 41.51 – 42.04 Mb Chr 4: 119.59 – 120 Mb PubMed search
Wikidata
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Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.

Function

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).

It regulates osteoblasts.

Interactions

HIVEP3 has been shown to interact with TRAF1 and TRAF2.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000127124 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028634 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hicar MD, Liu Y, Allen CE, Wu LC (January 2001). "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2". Genomics. 71 (1): 89–100. doi:10.1006/geno.2000.6425. PMID 11161801.
6. ^ "Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3".
7. Glimcher LH, Jones DC, Wein MN (November 2007). "Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3". Annals of the New York Academy of Sciences. 1116 (1): 174–181. Bibcode:2007NYASA1116..174G. doi:10.1196/annals.1402.044. PMID 18083927. S2CID 25260678.
8. ^ Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (January 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Molecular Cell. 9 (1): 121–131. doi:10.1016/S1097-2765(01)00434-8. PMID 11804591.

Further reading

• Rustgi AK, Van 't Veer LJ, Bernards R (November 1990). "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties". Proceedings of the National Academy of Sciences of the United States of America. 87 (22): 8707–8710. Bibcode:1990PNAS...87.8707R. doi:10.1073/pnas.87.22.8707. PMC 55028. PMID 2247438.
• Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–281. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (January 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Molecular Cell. 9 (1): 121–131. doi:10.1016/S1097-2765(01)00434-8. PMID 11804591.
• Oukka M, Wein MN, Glimcher LH (January 2004). "Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells". The Journal of Experimental Medicine. 199 (1): 15–24. doi:10.1084/jem.20030421. PMC 1887724. PMID 14707112.
• Qin H, Wang J, Liang Y, Taniguchi Y, Tanigaki K, Han H (2004). "RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2". Nucleic Acids Research. 32 (4): 1492–1501. doi:10.1093/nar/gkh295. PMC 390284. PMID 14999091.
• Hong JW, Wu LC (January 2005). "Structural characterization of the gene encoding the large zinc finger protein ZAS3: implication to the origin of multiple promoters in eukaryotic genes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1681 (2–3): 74–87. doi:10.1016/j.bbaexp.2004.10.004. PMID 15627499.
• Bettelli E, Dastrange M, Oukka M (April 2005). "Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells". Proceedings of the National Academy of Sciences of the United States of America. 102 (14): 5138–5143. Bibcode:2005PNAS..102.5138B. doi:10.1073/pnas.0501675102. PMC 555574. PMID 15790681.
• Li YJ, Deng J, Mayhew GM, Grimsley JW, Huo X, Vance JM (September 2007). "Investigation of the PARK10 gene in Parkinson disease". Annals of Human Genetics. 71 (Pt 5): 639–647. doi:10.1111/j.1469-1809.2007.00353.x. PMID 17388942. S2CID 22122597.

External links

• HIVEP3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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