Tryptophan—tRNA ligase - Misplaced Pages

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-tryptophan:tRNATrp ligase (AMP-forming). Other names in common use include tryptophanyl-tRNA synthetase, L-tryptophan-tRNATrp ligase (AMP-forming), tryptophanyl-transfer ribonucleate synthetase, tryptophanyl-transfer ribonucleic acid synthetase, tryptophanyl-transfer RNA synthetase, tryptophanyl ribonucleic synthetase, tryptophanyl-transfer ribonucleic synthetase, tryptophanyl-tRNA synthase, tryptophan translase, and TrpRS. This enzyme participates in tryptophan metabolism and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes 1D2R, 1I6K, 1I6L, 1I6M, 1M83, 1MAU, 1MAW, 1MB2, 1O5T, 1R6T, 1R6U, 1ULH, 1YIA, 1YID, 2A4M, 2AKE, 2AZX, 2DR2, 2G36, 2IP1, and 2OV4.

References

DAVIE EW, KONINGSBERGER VV, LIPMANN F (1956). "The isolation of a tryptophan-activating enzyme from pancreas". Arch. Biochem. Biophys. 65 (1): 21–38. doi:10.1016/0003-9861(56)90173-4. PMID 13373404.
Preddie EC (1969). "Tryptophanyl transfer ribonucleic acid synthetase from bovine pancreas. II. The chemically different subunits". J. Biol. Chem. 244 (14): 3958–68. doi:10.1016/S0021-9258(17)36442-6. PMID 5805407.
Wong KK, Meister A, Moldave K (1959). "Enzymic formation of ribonucleic acid-amino acid from synthetic aminoacyladenylate and ribonucleic acid". Biochim. Biophys. Acta. 36 (2): 531–533. doi:10.1016/0006-3002(59)90196-9. PMID 13845797.

v t e Enzymes: CO CS and CN ligases (EC 6.1-6.3)
6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine
6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase
6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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