Misplaced Pages

Small nucleolar RNA SNORA40

Article snapshot taken from[REDACTED] with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Member of the H/ACA class of small nucleolar RNA RNA family
Small nucleolar RNA SNORA40
Predicted secondary structure and sequence conservation of SNORA40
Identifiers
SymbolSNORA40
Alt. SymbolssnoACA40
RfamRF00561
Other data
RNA typeGene; snRNA; snoRNA; HACA-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000594
PDB structuresPDBe

In molecular biology, the small nucleolar RNA ACA40 belongs to the H/ACA family of snoRNAs and guides the pseudouridylation of 28S rRNA subunit at position U4565. snoRNA ACA40 was discovered using large-scale cloning by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residues 28S rRNA U4546 and 18S rRNA 1174. The pseudouridylation of these residues was reported by Ofengand and Bakin (1997) and Maden (1990). ACA1, ACA8, ACA18, ACA25, ACA32 and ACA40 and the C/D box snoRNAs mgh28S-2409 and mgh28S-2411 share the same host gene (MGC5306).

References

  1. ^ Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
  2. Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881. PMID 16373490.
  3. Ofengand, J; Bakin A (1997). "Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts". J Mol Biol. 266 (2): 246–268. doi:10.1006/jmbi.1996.0737. PMID 9047361.
  4. Maden BE (1990). "The numerous modified nucleotides in eukaryotic ribosomal RNA". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 39: 241–303. doi:10.1016/S0079-6603(08)60629-7. ISBN 9780125400398. PMID 2247610.

External links


Small nucleolar RNA
J
MB
Me
psi
R
SNORA
SNORD
snR
TBR
U
Z
other


Stub icon

This molecular or cell biology article is a stub. You can help Misplaced Pages by expanding it.

Categories:
Small nucleolar RNA SNORA40 Add topic