RTI-352 - Misplaced Pages

RTI-352
Names

IUPAC name Methyl 3α-(4-iodophenyl)tropane-2β-carboxylate
Systematic IUPAC name Methyl (1R,2S,3R,5S)-3-(4-iodophenyl)-8-methyl-8-azabicyclooctane-2-carboxylate
Other names RTI-4229-352
Identifiers
CAS Number	184376-53-2
3D model (JSmol)	Interactive image
ChemSpider	8018798
PubChem CID	9843083
UNII	LZD6F45MKX
CompTox Dashboard (EPA)	DTXSID601126180
InChI InChI=1S/C16H20INO2/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10/h3-6,12-15H,7-9H2,1-2H3/t12-,13-,14+,15-/m0/s1Key: SIIICDNNMDMWCI-XQLPTFJDSA-N
SMILES CN12CC1((OC)=O)(3=CC=C(I)C=C3)C2
Properties
Chemical formula	C₁₆H₂₀INO₂
Molar mass	385.245 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references

Chemical compound

RTI-352 is a phenyltropane that is used as a radiolabeling ligand for the DAT.

RTI-352 is a geometric isomer of RTI-55 (β-CIT).

Based on X-ray crystallography, this compound is in a tautomeric equilibrium residing mostly on the side of the boat-shaped conformer.

References

U.S. patent 6,358,492
Zhan, Yougen; Saindane, Amit M.; Scheffel, Ursula; Carroll, F. Ivy; Holmquist, Christopher R.; Kepler, John A.; Taylor, George F.; Kuhar, Michael J. (1997). "RTI-352: A 3α Analogue of RTI-55 as an in vivo dopamine transporter binding ligand". Synapse. 25 (4): 389–392. doi:10.1002/(SICI)1098-2396(199704)25:4<389::AID-SYN10>3.0.CO;2-Q. PMID 9097398.

v t e Phenyltropanes (classifications)
2-Carboxymethyl Esters	Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83
(3,4-Disubstituted Phenyl)-tropanes	Dichloropane RTI-112 RTI-353
Arylcarboxy	RTI-113 RTI-120
Carboxyalkyl	RTI-121 RTI-150
Acyl	PTT/WF-11 WF-23 PIT/WF-21 WF-33
β,α Stereochemistry	RTI-352 RTI-274
α,β Stereochemistry	Brasofensine Tesofensine NS2359
Heterocycles: 3-Substituted-isoxazol-5-yl	RTI-177 RTI-336 RTI-371
Heterocycles: 3-Substituted-1,2,4-oxadiazole	RTI-126 RTI-371
N-alkyl	FP-β-CPPIT FE-β-CPPIT Altropane Ioflupane (I)
N-replaced (S,O,C)	Tropoxane
Irreversible	RTI-76
Nortropanes (N-demethylated)	NS2359 (GSK-372,475)

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