Peforelin - Misplaced Pages

Chemical compound Pharmaceutical compound

Peforelin
Clinical data

Trade names	Maprelin
Other names	Lamprey GnRH-III; H-Pyr-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH₂; XHWSHDWKPG
Routes of administration	Injection
Drug class	GnRH agonist
Identifiers
IUPAC name (3S)-4-pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-oxobutanoic acid
CAS Number	147859-97-0
PubChem CID	16197823
ChemSpider	17326238
UNII	UJ8NQ5Z0VX
CompTox Dashboard (EPA)	DTXSID30163819
ECHA InfoCard	100.223.356
Chemical and physical data
Formula	C₅₉H₇₄N₁₈O₁₄
Molar mass	1259.353 g·mol
3D model (JSmol)	Interactive image
SMILES NCCCC(NC(=O)(Cc1cc2ccccc12)NC(=O)(CC(=O)O)NC(=O)(Cc1cnc1)NC(=O)(CO)NC(=O)(Cc1cc2ccccc12)NC(=O)(Cc1cnc1)NC(=O)1CCC(=O)N1)C(=O)N1CCC1C(=O)NCC(N)=O
InChI InChI=1S/C59H74N18O14/c60-16-6-5-12-40(59(91)77-17-7-13-47(77)58(90)66-27-48(61)79)70-52(84)41(18-31-23-64-37-10-3-1-8-35(31)37)72-56(88)45(22-50(81)82)75-55(87)44(21-34-26-63-30-68-34)74-57(89)46(28-78)76-53(85)42(19-32-24-65-38-11-4-2-9-36(32)38)71-54(86)43(20-33-25-62-29-67-33)73-51(83)39-14-15-49(80)69-39/h1-4,8-11,23-26,29-30,39-47,64-65,78H,5-7,12-22,27-28,60H2,(H2,61,79)(H,62,67)(H,63,68)(H,66,90)(H,69,80)(H,70,84)(H,71,86)(H,72,88)(H,73,83)(H,74,89)(H,75,87)(H,76,85)(H,81,82)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 Key:RTASYRSYWSLWJV-CSYZDTNESA-N

Peforelin (INNTooltip International Nonproprietary Name), or peforelin acetate, sold under the brand name Maprelin, is a gonadotropin-releasing hormone agonist (GnRH agonist) medication which is used in veterinary medicine in Europe and Canada. It is a GnRH analogue and a synthetic peptide, specifically a decapeptide. The drug was introduced for veterinary use by 2001.

References

GnRHTooltip Gonadotropin-releasing hormone and gonadotropins

Preparations	Follicle-stimulating hormone Human chorionic gonadotropin Luteinizing hormone Menotropin Urofollitropin

Others
(indirect)

Sex steroid antagonists (via disinhibition of the HPG axis): Antiandrogens (e.g., flutamide, bicalutamide, enzalutamide)
Antiestrogens/SERMsTooltip Selective estrogen receptor modulators (e.g., tamoxifen, clomifene, enclomifene)
Aromatase inhibitors (e.g., anastrozole)
GnRH agonists (e.g., GnRHTooltip gonadotropin-releasing hormone)

See also: GnRH and gonadotropin receptor modulators; Androgens and antiandrogens; Estrogens and antiestrogens; Progestogens and antiprogestogens

GnRHTooltip Gonadotropin-releasing hormone receptor and gonadotropin receptor modulators

GnRHTooltip Gonadotropin-releasing hormone receptor

LH/hCGTooltip Luteinizing hormone/choriogonadotropin receptor

FSHTooltip Follicle-stimulating hormone receptor

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