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PIGC

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Enzyme
PIGC
Identifiers
AliasesPIGC, GPI2, phosphatidylinositol glycan anchor biosynthesis class C, MRT62, GPIBD16
External IDsOMIM: 601730; MGI: 1914542; HomoloGene: 7109; GeneCards: PIGC; OMA:PIGC - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for PIGCGenomic location for PIGC
Band1q24.3Start172,370,189 bp
End172,444,086 bp
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)
Chromosome 1 (mouse)Genomic location for PIGCGenomic location for PIGC
Band1|1 H2.1Start161,796,755 bp
End161,801,004 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • skin of leg

  • skin of abdomen

  • islet of Langerhans

  • monocyte

  • skin of thigh

  • nipple

  • body of pancreas

  • bone marrow

  • hair follicle
Top expressed in
  • seminal vesicula

  • cornea

  • renal corpuscle

  • calvaria

  • epithelium of lens

  • temporal muscle

  • upper arm

  • molar

  • primary oocyte

  • triceps brachii muscle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5279

67292

Ensembl

ENSG00000135845

ENSMUSG00000026698

UniProt

Q92535

Q9CXR4

RefSeq (mRNA)

NM_153747
NM_002642

NM_001039045
NM_026078

RefSeq (protein)

NP_002633
NP_714969

NP_001034134
NP_080354

Location (UCSC)Chr 1: 172.37 – 172.44 MbChr 1: 161.8 – 161.8 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized.

Interactions

PIGC has been shown to interact with PIGQ.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000135845Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026698Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Inoue N, Watanabe R, Takeda J, Kinoshita T (Oct 1996). "PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2". Biochem Biophys Res Commun. 226 (1): 193–9. doi:10.1006/bbrc.1996.1332. PMID 8806613.
  6. Hong Y, Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Nov 1997). "Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1". Genomics. 44 (3): 347–9. doi:10.1006/geno.1997.4893. PMID 9325057.
  7. ^ "Entrez Gene: PIGC phosphatidylinositol glycan anchor biosynthesis, class C".
  8. Watanabe, R; Inoue N; Westfall B; Taron C H; Orlean P; Takeda J; Kinoshita T (Feb 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. 17 (4). ENGLAND: 877–85. doi:10.1093/emboj/17.4.877. ISSN 0261-4189. PMC 1170437. PMID 9463366.

Further reading


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