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PFKFB1

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Protein-coding gene in the species Homo sapiens
PFKFB1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1K6M

Identifiers
AliasesPFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
External IDsOMIM: 311790; MGI: 107816; HomoloGene: 105654; GeneCards: PFKFB1; OMA:PFKFB1 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)
X chromosome (human)Genomic location for PFKFB1Genomic location for PFKFB1
BandXp11.21Start54,932,961 bp
End54,998,534 bp
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)
X chromosome (mouse)Genomic location for PFKFB1Genomic location for PFKFB1
BandX|X F3Start149,371,225 bp
End149,426,874 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • right lobe of liver

  • gastrocnemius muscle

  • Skeletal muscle tissue of rectus abdominis

  • gonad

  • vastus lateralis muscle

  • muscle of arm

  • biceps brachii

  • testicle

  • triceps brachii muscle
Top expressed in
  • muscle of thigh

  • sternocleidomastoid muscle

  • vastus lateralis muscle

  • triceps brachii muscle

  • masseter muscle

  • tibialis anterior muscle

  • temporal muscle

  • digastric muscle

  • gastrocnemius muscle

  • right ventricle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5207

18639

Ensembl

ENSG00000158571

ENSMUSG00000025271

UniProt

P16118

P70266

RefSeq (mRNA)

NM_001271804
NM_001271805
NM_002625

NM_008824
NM_001374170
NM_001374171
NM_001374172
NM_001374173

NM_001374175

RefSeq (protein)

NP_001258733
NP_001258734
NP_002616

NP_032850
NP_001361099
NP_001361100
NP_001361101
NP_001361102

NP_001361104

Location (UCSC)Chr X: 54.93 – 55 MbChr X: 149.37 – 149.43 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000158571Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025271Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Batra RS, Hatchwell E, Rider S, Brown R, Brown GK, Craig IW (Apr 1997). "Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21". Genomics. 40 (2): 358–61. doi:10.1006/geno.1996.4530. PMID 9119406.
  6. ^ "Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1".

Further reading

PDB gallery
  • 1c7z: REGULATORY COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE 1c7z: REGULATORY COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE
  • 1c80: REGULATORY COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE 1c80: REGULATORY COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE
  • 1c81: MICHAELIS COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE 1c81: MICHAELIS COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE
  • 1fbt: THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 1fbt: THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE
  • 1k6m: Crystal Structure of Human Liver 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 1k6m: Crystal Structure of Human Liver 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase
  • 1tip: THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 1tip: THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE
Metabolism: carbohydrate metabolism: glycolysis/gluconeogenesis enzymes
Glycolysis
Gluconeogenesis only
to oxaloacetate:
from lactate (Cori cycle):
from alanine (Alanine cycle):
from glycerol:
Regulatory


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