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Louise Rollins-Smith

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Immunology researcher
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Louise Rollins-Smith
NationalityAmerican
Alma materHamline University, University of Minnesota
Scientific career
FieldsImmunology, Amphibians, Antimicrobial peptides
InstitutionsVanderbilt University
Thesis (1977)

Louise Rollins-Smith is a professor of biological sciences, professor of pediatrics, and a professor of pathology, microbiology and immunology at Vanderbilt University. She is known for her work investigating host-pathogen interactions using amphibians as model organisms.

Education and career

Rollins-Smith received her Bachelor's degree in Biology at Hamline University, Saint Paul, Minnesota, before completing a Masters and a Ph.D. in zoology at the University of Minnesota in 1977. Rollins-Smith was a postdoctoral researcher at the University of Rochester before joining Vanderbilt University in 1984.

Research

Rollins-Smith has studied disease and immunity in amphibians. Her early research was focused upon Lucké renal adenocarcinoma of leopard frogs, the development of immunological tolerance and immune changes at metamorphosis in frogs. Rollins-Smith has also studied the effects of immunotoxic and agricultural chemicals on amphibian immunity. Rollins-Smith's research has examined the link between widespread amphibian declines and the amphibian chytrid fungi, Bactrochochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal), particularly in relation to amphibian immunity. Rollins-Smith has also become known for her work on amphibian skin antimicrobial peptides (AMPs). Alongside her colleagues, she has provided evidence that the effectiveness of AMPs is a valuable predictor of amphibian species susceptibility to the Bd, and that AMPs are potent inhibitors of viral infection, including HIV infection of human T lymphocytes.

Selected publications

References

  1. "Vanderbilt University School of Medicine". wag.app.vanderbilt.edu. Retrieved 2023-12-12.
  2. "Rollins-Smith Lab Members | The Rollins-Smith Lab". www.vumc.org. Retrieved 2023-12-12.
  3. Rollins-Smith, Louise A.; Cohen, Nicholas (September 1984). "Effect of Thyroxine on Induction of Lucké Renal Adenocarcinomas in Lucké Tumor Herpesvirus-Infected Leopard Frog Tadpoles2". JNCI: Journal of the National Cancer Institute. 73 (3): 717–720. doi:10.1093/jnci/73.3.717. ISSN 1460-2105. PMID 6332231.
  4. Rollins-Smith, Louise A.; Cohen, Nicholas (January 1982). "Effect of Thymectomy on Development of Lucké Renal Adenocarcinomas in Virus-Infected Leopard Frog Tadpoles23". JNCI: Journal of the National Cancer Institute. 68 (1): 133–138. doi:10.1093/jnci/68.1.133. ISSN 1460-2105.
  5. Rollins-Smith, Louise A.; Blair, Patrick J.; Davis, A. Tray (1992). "Thymus Ontogeny in Frogs: T-Cell Renewal at Metamorphosis". Journal of Immunology Research. 2 (3): 207–213. doi:10.1155/1992/26251. ISSN 2314-8861. PMC 2275863. PMID 1320967.
  6. Rollins-Smith, Louise A.; Hopkins, B. Diane (1997-03-01). "F2 2:00 Immunotoxic effects of diazinon and lead on the developing hematopoietic system of Xenopus laevis". Developmental & Comparative Immunology. The 7th Congress of The International Society of Developmental and Comparative Immunology. 21 (2): 121. doi:10.1016/S0145-305X(97)88572-2. ISSN 0145-305X.
  7. Christin, M. S.; Ménard, L.; Gendron, A. D.; Ruby, S.; Cyr, D.; Marcogliese, D. J.; Rollins-Smith, L.; Fournier, M. (2004-03-30). "Effects of agricultural pesticides on the immune system of Xenopus laevis and Rana pipiens". Aquatic Toxicology. 67 (1): 33–43. Bibcode:2004AqTox..67...33C. doi:10.1016/j.aquatox.2003.11.007. ISSN 0166-445X. PMID 15019249.
  8. "Amphibian population on the decline". Stewart-Houston Times. 1998-10-27. p. 15. Retrieved 2025-01-07.
  9. Brown, Josh (2014-07-14). "Scientists find new weapon to fight deadly frog virus". The Tennessean. pp. A13. Retrieved 2025-01-07.
  10. Phelan, Meagan (17 October 2013). "Fatal Frog Fungus Maneuvers Past Immune System". American Association for the Advancement of Science (AAAS). Retrieved 2025-01-07.
  11. Rollins-Smith, Louise A.; Doersam, Jennifer K.; Longcore, Joyce E.; Taylor, Sharon K.; Shamblin, Jessica C.; Carey, Cynthia; Zasloff, Michael A. (2002-01-01). "Antimicrobial peptide defenses against pathogens associated with global amphibian declines". Developmental & Comparative Immunology. 26 (1): 63–72. doi:10.1016/S0145-305X(01)00041-6. ISSN 0145-305X. PMID 11687264.
  12. Pinto, Claudia (2005-10-21). "Frog secretions block HIV infections, VU study finds". The Tennessean. pp. A1, . Retrieved 2025-01-07.

External links

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