Misplaced Pages

L-745,870

Article snapshot taken from[REDACTED] with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Chemical compound Pharmaceutical compound
L-745,870
Identifiers
IUPAC name
  • 3-(methyl)-1H-pyrrolopyridine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H19ClN4
Molar mass326.83 g·mol
3D model (JSmol)
SMILES
  • c1cc2c(cc2nc1)CN3CCN(CC3)c4ccc(cc4)Cl
InChI
  • InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
  • Key:OGJGQVFWEPNYSB-UHFFFAOYSA-N
  (what is this?)  (verify)

L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.

References

  1. Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist". Trends in Pharmacological Sciences. 18 (6): 186–8. doi:10.1016/s0165-6147(97)01066-3. PMID 9226994.
  2. Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004). "Regulation of working memory by dopamine D4 receptor in rats". Neuropsychopharmacology. 29 (9): 1648–55. doi:10.1038/sj.npp.1300491. PMID 15138447.
  3. Moustgaard A, Hau J, Lind NM (2008). "Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats". Behavioral and Brain Functions. 4: 49. doi:10.1186/1744-9081-4-49. PMC 2577092. PMID 18945334.
Dopamine receptor modulators
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists


Stub icon

This drug article relating to the nervous system is a stub. You can help Misplaced Pages by expanding it.

Categories:
L-745,870 Add topic