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G2E3
Identifiers
Aliases	G2E3, KIAA1333, PHF7B, G2/M-phase specific E3 ubiquitin protein ligase
External IDs	OMIM: 611299; MGI: 2444298; HomoloGene: 32362; GeneCards: G2E3; OMA:G2E3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q12 Start 30,559,158 bp End 30,620,064 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 B3 Start 51,394,844 bp End 51,423,769 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm testicle gonad ventricular zone right testis left testis ganglionic eminence pancreatic epithelial cell epithelium of colon Achilles tendon Top expressed in hand Rostral migratory stream superior cervical ganglion epiblast tail of embryo genital tubercle primitive streak maxillary prominence medial ganglionic eminence spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding metal ion binding transferase activity Cellular component cytoplasm nucleolus nucleus cytosol intracellular membrane-bounded organelle Biological process multicellular organism development protein ubiquitination apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55632 217558 Ensembl ENSG00000092140 ENSMUSG00000035293 UniProt Q7L622 Q5RJY2 RefSeq (mRNA) NM_001308097 NM_017769 NM_001015099 NM_001167963 NM_001167964 RefSeq (protein) NP_001295026 NP_060239 NP_001015099 NP_001161435 NP_001161436 Location (UCSC) Chr 14: 30.56 – 30.62 Mb Chr 12: 51.39 – 51.42 Mb PubMed search
Wikidata
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G2/M phase-specific E3 ubiquitin-protein ligase is an enzyme that in humans is encoded by the G2E3 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000092140 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000035293 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brooks WS, Helton ES, Banerjee S, Venable M, Johnson L, Schoeb TR, Kesterson RA, Crawford DF (Aug 2008). "G2E3 is a dual function ubiquitin ligase required for early embryonic development". J Biol Chem. 283 (32): 22304–15. doi:10.1074/jbc.M803238200. PMC 2494922. PMID 18511420.
6. Brooks WS, Banerjee S, Crawford DF (Feb 2007). "G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization". Exp Cell Res. 313 (4): 665–76. doi:10.1016/j.yexcr.2006.11.020. PMC 1876774. PMID 17239372.
7. "Entrez Gene: KIAA1333 KIAA1333".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Crawford DF, Piwnica-Worms H (2001). "The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators". J. Biol. Chem. 276 (40): 37166–77. doi:10.1074/jbc.M103414200. PMID 11483598.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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