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ITGA6
Identifiers
Aliases	ITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6, JEB6
External IDs	OMIM: 147556; MGI: 96605; HomoloGene: 20091; GeneCards: ITGA6; OMA:ITGA6 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q31.1 Start 172,427,354 bp End 172,506,459 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 C2- C3|2 42.79 cM Start 71,575,960 bp End 71,688,760 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve sural nerve spinal ganglia trigeminal ganglion epithelium of colon Achilles tendon rectum pylorus tendon of biceps brachii duodenum Top expressed in sciatic nerve epithelium of stomach secondary oocyte atrium epithelium of lens left lung lobe crypt of lieberkuhn of small intestine endothelial cell of lymphatic vessel pyloric antrum left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding integrin binding protein binding laminin binding neuregulin binding protein-containing complex binding insulin-like growth factor I binding cadherin binding Cellular component integral component of membrane membrane focal adhesion basal part of cell plasma membrane hemidesmosome basement membrane cell surface integrin complex basal plasma membrane basolateral plasma membrane external side of plasma membrane integrin alpha6-beta4 complex filopodium Biological process cellular response to extracellular stimulus hemidesmosome assembly renal system development nail development positive regulation of cell-cell adhesion filopodium assembly negative regulation of extrinsic apoptotic signaling pathway extracellular matrix organization odontogenesis of dentin-containing tooth cell-substrate adhesion positive regulation of GTPase activity cell adhesion cell adhesion mediated by integrin brown fat cell differentiation positive regulation of apoptotic process cell-substrate junction assembly integrin-mediated signaling pathway positive regulation of phosphorylation cell-matrix adhesion digestive tract development ectodermal cell differentiation leukocyte migration skin development positive regulation of transcription by RNA polymerase II amelogenesis cellular response to organic cyclic compound positive regulation of cell-substrate adhesion positive regulation of cell migration cell-cell adhesion positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3655 16403 Ensembl ENSG00000091409 ENSMUSG00000027111 UniProt P23229 Q61739 RefSeq (mRNA) NM_000210 NM_001079818 NM_001316306 NM_001365529 NM_001365530 NM_001394928 NM_001277970 NM_008397 RefSeq (protein) NP_000201 NP_001073286 NP_001303235 NP_001352458 NP_001352459 NP_001264899 NP_032423 NP_001393187 Location (UCSC) Chr 2: 172.43 – 172.51 Mb Chr 2: 71.58 – 71.69 Mb PubMed search
Wikidata
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Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

Function

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.

Interactions

ITGA6 has been shown to interact with TSPAN4 and GIPC1.

See also

• Cluster of differentiation
• Integrins

References

1. ^ GRCh38: Ensembl release 89: ENSG00000091409 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027111 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ITGA6 integrin, alpha 6".
6. De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, et al. (October 2017). "Hemidesmosome integrity protects the colon against colitis and colorectal cancer". Gut. 66 (10): 1748–1760. doi:10.1136/gutjnl-2015-310847. PMC 5595104. PMID 27371534.
7. Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
8. Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.

Further reading

• Lipscomb EA, Mercurio AM (September 2005). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer and Metastasis Reviews. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729. S2CID 26150860.

External links

• CD49f+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• ITGA6 Info with links in the Cell Migration Gateway Archived 11 December 2014 at the Wayback Machine

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• Genes on human chromosome 2
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