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IGHG3

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Gene in the species Homo sapiens

IGHG3

Identifiers

IGHG3, IgG3, immunoglobulin heavy constant gamma 3 (G3m marker)

External IDs

OMIM: 147120; GeneCards: IGHG3; OMA:IGHG3 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)

Band	14q32.33	Start	105,764,503 bp
Band	14q32.33	End	105,771,405 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

lymph node

spleen

bone marrow cells

appendix

olfactory zone of nasal mucosa

upper lobe of left lung

tonsil

gallbladder

left uterine tube

right coronary artery

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More reference expression data

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Species

Human

Mouse


3502


n/a


ENSG00000211897


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n a


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RefSeq (mRNA)


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RefSeq (protein)


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Location (UCSC)

Chr 14: 105.76 – 105.77 Mb

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PubMed search

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View/Edit Human

Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene.

References

^ GRCh38: Ensembl release 89: ENSG00000211897 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Alexander A, Steinmetz M, Barritault D, Frangione B, Franklin EC, Hood L, Buxbaum JN (Sep 1982). "gamma Heavy chain disease in man: cDNA sequence supports partial gene deletion model". Proc Natl Acad Sci U S A. 79 (10): 3260–4. Bibcode:1982PNAS...79.3260A. doi:10.1073/pnas.79.10.3260. PMC 346395. PMID 6808505.
"Entrez Gene: IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)".

Further reading

Michaelsen TE, Frangione B, Franklin EC (1977). "Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit". J. Biol. Chem. 252 (3): 883–9. doi:10.1016/S0021-9258(19)75181-3. PMID 402363.
Wolfenstein-Todel C, Frangione B, Prelli F, Franklin EC (1976). "The amino acid sequence of "heavy chain disease" protein ZUC. Structure of the Fc fragment of immunoglobulin G3". Biochem. Biophys. Res. Commun. 71 (4): 907–14. doi:10.1016/0006-291X(76)90741-5. PMID 823945.
Huck S, Fort P, Crawford DH, et al. (1986). "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes". Nucleic Acids Res. 14 (4): 1779–89. doi:10.1093/nar/14.4.1779. PMC 339572. PMID 3081877.
Frangione B, Rosenwasser E, Prelli F, Franklin EC (1980). "Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis". Biochemistry. 19 (18): 4304–8. doi:10.1021/bi00559a024. PMID 6774747.
Lewis AP, Lemon SM, Barber KA, et al. (1993). "Rescue, expression, and analysis of a neutralizing human anti-hepatitis A virus monoclonal antibody". J. Immunol. 151 (5): 2829–38. doi:10.4049/jimmunol.151.5.2829. PMID 8395549. S2CID 24962823.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.

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