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IGHG1

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Gene in the species Homo sapiens

IgG1 B12 heterotetramer, Human.

IGHG1

Identifiers

IGHG1, immunoglobulin heavy constant gamma 1 (G1m marker)

External IDs

OMIM: 147100; GeneCards: IGHG1; OMA:IGHG1 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)

Band	14q32.33	Start	105,736,343 bp
Band	14q32.33	End	105,743,071 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

spleen

lymph node

appendix

bone marrow cells

gallbladder

olfactory zone of nasal mucosa

duodenum

right coronary artery

rectum

upper lobe of left lung

n/a

More reference expression data

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Species

Human

Mouse


3500


n/a


ENSG00000211896


n/a


n a


n/a

RefSeq (mRNA)


n/a


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RefSeq (protein)


n/a


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Location (UCSC)

Chr 14: 105.74 – 105.74 Mb

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PubMed search

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View/Edit Human

Ig gamma-1 chain C region is a protein that in humans is encoded by the IGHG1 gene.

References

^ GRCh38: Ensembl release 89: ENSG00000211896 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)".

Further reading

Ponstingl H, Hilschmann N (1977). "". Hoppe-Seyler's Z. Physiol. Chem. 357 (11): 1571–604. doi:10.1515/bchm2.1976.357.2.1571. PMID 826475.
Dreker L, Schwarz J, Reichel W, Hilschmann N (1977). "". Hoppe-Seyler's Z. Physiol. Chem. 357 (11): 1515–40. doi:10.1515/bchm2.1976.357.2.1515. PMID 1002129.
Brady RL, Edwards DJ, Hubbard RE, et al. (1992). "Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells". J. Mol. Biol. 227 (1): 253–64. doi:10.1016/0022-2836(92)90695-G. PMID 1522589.
Gall WE, Edelman GM (1971). "The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds". Biochemistry. 9 (16): 3188–96. doi:10.1021/bi00818a011. PMID 4923144.
Cunningham BA, Rutishauser U, Gall WE, et al. (1971). "The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1-H4". Biochemistry. 9 (16): 3161–70. doi:10.1021/bi00818a008. PMID 5489771.
Rutishauser U, Cunningham BA, Bennett C, et al. (1971). "The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments H5-H7". Biochemistry. 9 (16): 3171–81. doi:10.1021/bi00818a009. PMID 5530842.
Ellison JW, Berson BJ, Hood LE (1982). "The nucleotide sequence of a human immunoglobulin C gamma1 gene". Nucleic Acids Res. 10 (13): 4071–9. doi:10.1093/nar/10.13.4071. PMC 320779. PMID 6287432.
Takahashi N, Ueda S, Obata M, et al. (1982). "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family". Cell. 29 (2): 671–9. doi:10.1016/0092-8674(82)90183-0. PMID 6811139. S2CID 31733882.
Schmidt WE, Jung HD, Palm W, Hilschmann N (1983). "". Hoppe-Seyler's Z. Physiol. Chem. 364 (6): 713–47. doi:10.1515/bchm2.1983.364.1.713. PMID 6884994.
Deisenhofer J (1981). "Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution". Biochemistry. 20 (9): 2361–70. doi:10.1021/bi00512a001. PMID 7236608.
Paterson T, Innes J, McMillan L, et al. (1998). "Variation in IgG1 heavy chain allotype does not contribute to differences in biological activity of two human anti-Rhesus (D) monoclonal antibodies". Immunotechnology. 4 (1): 37–47. doi:10.1016/S1380-2933(98)00005-0. PMID 9661813.
Masat L, Caldwell J, Armstrong R, et al. (2000). "Association of SWAP-70 with the B cell antigen receptor complex". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2180–4. Bibcode:2000PNAS...97.2180M. doi:10.1073/pnas.040374497. PMC 15774. PMID 10681448.
Sondermann P, Huber R, Oosthuizen V, Jacob U (2000). "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex". Nature. 406 (6793): 267–73. doi:10.1038/35018508. PMID 10917521. S2CID 4306592.
Hotta K, Lange H, Tantillo DJ, et al. (2000). "Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8". J. Mol. Biol. 302 (5): 1213–25. doi:10.1006/jmbi.2000.4503. PMID 11183784.
McLean GR, Nakouzi A, Casadevall A, Green NS (2001). "Human and murine immunoglobulin expression vector cassettes". Mol. Immunol. 37 (14): 837–45. doi:10.1016/S0161-5890(00)00101-2. PMID 11257305.
Karpusas M, Lucci J, Ferrant J, et al. (2001). "Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody". Structure. 9 (4): 321–9. doi:10.1016/S0969-2126(01)00590-1. PMID 11525169.
Mimura Y, Sondermann P, Ghirlando R, et al. (2002). "Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding". J. Biol. Chem. 276 (49): 45539–47. doi:10.1074/jbc.M107478200. PMID 11567028.
Pandey JP, Frederick M (2002). "TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis". Hum. Immunol. 63 (6): 485–91. doi:10.1016/S0198-8859(02)00399-3. PMID 12039524.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

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