Hydrocholeretics are substances that increase the volume of secretion of bile from the liver without increasing the amount of solids secreted. Some substances can result in decreased solid production, possibly due to circulatory effects.
Cyclobutyrol is a compound commonly used as a hydrocholeretic. Its effects in rats include a dose-dependent increase in bile flow, sodium, potassium, chloride and bicarbonate outputs and reduced bile acid concentrations.
See also
References
- Textbook of Biochemistry and Human Biology, by G. P. Talwar, Talwar & Srivastava (eds.), L. M. Srivastava, p.610.
- Brauer, R. W.; Pessotti, R. L. (1952). "The Effect of Choleretic and of Hydrocholeretic Agents on Bile Flow and Bile Solids in the Isolated Perfused Liver". Science. 115 (2980): 142–143. Bibcode:1952Sci...115..142B. doi:10.1126/science.115.2980.142. PMID 14913193.
- Monte, MJ (1990). "Choleretic mechanism and effects of cyclobutyrol in the rat: dose-response relationship". Biomed Biochim Acta. 49 (1): 83–90. PMID 2360911.
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