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G3BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q90, 4FCJ, 4FCM, 4IIA
Identifiers
Aliases	G3BP1, G3BP, HDH-VIII, G3BP stress granule assembly factor 1
External IDs	OMIM: 608431; MGI: 1351465; HomoloGene: 38096; GeneCards: G3BP1; OMA:G3BP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q33.1 Start 151,771,045 bp End 151,812,911 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B1.3 Start 55,360,511 bp End 55,395,664 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone epithelium of colon ganglionic eminence gonad islet of Langerhans stromal cell of endometrium Achilles tendon tonsil muscle of thigh gastrocnemius muscle Top expressed in Ileal epithelium ventricular zone corneal stroma lactiferous gland embryo embryo tail of embryo plantaris muscle epiblast extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding helicase activity DNA helicase activity protein binding nucleic acid binding nuclease activity endonuclease activity ATP binding hydrolase activity mRNA binding RNA binding Cellular component membrane focal adhesion plasma membrane intracellular anatomical structure cytoplasmic stress granule nucleus cytoplasm cytosol perikaryon ribonucleoprotein complex Biological process nucleic acid phosphodiester bond hydrolysis Ras protein signal transduction negative regulation of canonical Wnt signaling pathway DNA duplex unwinding transport stress granule assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10146 27041 Ensembl ENSG00000145907 ENSMUSG00000018583 UniProt Q13283 P97855 RefSeq (mRNA) NM_005754 NM_198395 NM_013716 RefSeq (protein) NP_005745 NP_938405 NP_038744 Location (UCSC) Chr 5: 151.77 – 151.81 Mb Chr 11: 55.36 – 55.4 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

G3BP1 can initiate stress granule formation and labeled G3BP1 is commonly used as a marker for stress granules.

Interactions

G3BP1 has been shown to interact with USP10. It also interacts with SND1.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000145907 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000018583 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B (Jul 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561–9. doi:10.1128/MCB.16.6.2561. PMC 231246. PMID 8649363.
6. Costa M, Ochem A, Staub A, Falaschi A (Mar 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Res. 27 (3): 817–21. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.
7. ^ "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".
8. Annibaldi, A; Dousse, A; Martin, S; Tazi, J; Widmann, C (2011). "Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1". PLOS ONE. 6 (12): e29024. Bibcode:2011PLoSO...629024A. doi:10.1371/journal.pone.0029024. PMC 3242762. PMID 22205990.
9. Mahboubi, Hicham; Stochaj, Ursula (2017-04-01). "Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863 (4): 884–895. doi:10.1016/j.bbadis.2016.12.022. ISSN 0925-4439. PMID 28095315.
10. Soncini, C; Berdo I; Draetta G (Jun 2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. 20 (29). England: 3869–79. doi:10.1038/sj.onc.1204553. ISSN 0950-9232. PMID 11439350.

Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J., Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions.FEBS Letters, Volume 584, Issue 16, Pages 3525-3532.

Further reading

• Irvine K, Stirling R, Hume D, Kennedy D (2005). "Rasputin, more promiscuous than ever: a review of G3BP". Int. J. Dev. Biol. 48 (10): 1065–77. doi:10.1387/ijdb.041893ki. PMID 15602692.
• Onno M, Nakamura T, Hillova J, Hill M (1993). "Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes". Oncogene. 7 (12): 2519–23. PMID 1461655.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Gallouzi IE, Parker F, Chebli K, et al. (1998). "A Novel Phosphorylation-Dependent RNase Activity of GAP-SH3 Binding Protein: a Potential Link between Signal Transduction and RNA Stability". Mol. Cell. Biol. 18 (7): 3956–65. doi:10.1128/MCB.18.7.3956. PMC 108980. PMID 9632780.
• Kociok N, Esser P, Unfried K, et al. (1999). "Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells". J. Cell. Biochem. 74 (2): 194–201. doi:10.1002/(SICI)1097-4644(19990801)74:2<194::AID-JCB5>3.0.CO;2-M. PMID 10404389. S2CID 8259980.
• Soncini C, Berdo I, Draetta G (2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. 20 (29): 3869–79. doi:10.1038/sj.onc.1204553. PMID 11439350.
• Tourrière H, Gallouzi IE, Chebli K, et al. (2001). "RasGAP-Associated Endoribonuclease G3BP: Selective RNA Degradation and Phosphorylation-Dependent Localization". Mol. Cell. Biol. 21 (22): 7747–60. doi:10.1128/MCB.21.22.7747-7760.2001. PMC 99945. PMID 11604510.
• Barnes CJ, Li F, Mandal M, et al. (2002). "Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors". Cancer Res. 62 (5): 1251–5. PMID 11888885.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Katsafanas GC, Moss B (2005). "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer". J. Biol. Chem. 279 (50): 52210–7. doi:10.1074/jbc.M411033200. PMID 15471883.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nat. Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174. S2CID 6654604.

External links

• G3BP1 human gene location in the UCSC Genome Browser.
• G3BP1 human gene details in the UCSC Genome Browser.

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