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FKBP10

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Protein-coding gene in the species Homo sapiens
FKBP10
Identifiers
AliasesFKBP10, FKBP65, OI11, OI6, PPIASE, hFKBP65, BRKS1, FK506 binding protein 10, FKBP prolyl isomerase 10
External IDsOMIM: 607063; MGI: 104769; HomoloGene: 7718; GeneCards: FKBP10; OMA:FKBP10 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for FKBP10Genomic location for FKBP10
Band17q21.2Start41,812,680 bp
End41,823,213 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for FKBP10Genomic location for FKBP10
Band11 D|11 63.47 cMStart100,306,523 bp
End100,315,650 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • ascending aorta

  • Descending thoracic aorta

  • anterior pituitary

  • right coronary artery

  • right ovary

  • canal of the cervix

  • body of uterus

  • left ovary

  • left coronary artery
Top expressed in
  • calvaria

  • internal carotid artery

  • external carotid artery

  • body of femur

  • fossa

  • molar

  • vas deferens

  • vestibular sensory epithelium

  • stroma of bone marrow

  • dermis
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

60681

14230

Ensembl

ENSG00000141756

ENSMUSG00000001555

UniProt

Q96AY3

Q61576

RefSeq (mRNA)

NM_021939

NM_001163481
NM_010221

RefSeq (protein)

NP_068758

NP_001156953
NP_034351

Location (UCSC)Chr 17: 41.81 – 41.82 MbChr 11: 100.31 – 100.32 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene.

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular chaperones. Two alternatively spliced variants, which encode different isoform, are reported.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000141756Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000001555Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Patterson CE, Schaub T, Coleman EJ, Davis EC (Feb 2001). "Developmental Regulation of FKBP65: An ER-localized Extracellular Matrix Binding-Protein". Mol Biol Cell. 11 (11): 3925–35. doi:10.1091/mbc.11.11.3925. PMC 15047. PMID 11071917.
  6. Ishikawa Y, Vranka J, Wirz J, Nagata K, Bachinger HP (Nov 2008). "The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens". J Biol Chem. 283 (46): 31584–90. doi:10.1074/jbc.M802535200. PMID 18786928.
  7. ^ "Entrez Gene: FKBP10 FK506 binding protein 10, 65 kDa".

Further reading

Isomerases: geometric (EC 5.2)
5.2.1
Enzymes
Activity
Regulation
Classification
Kinetics
Types
Portal:


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