Misplaced Pages

Diiodotyrosine

Article snapshot taken from[REDACTED] with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Not to be confused with diiodothyronine.
Diiodotyrosine
Skeletal formula of diiodotyrosine
Ball-and-stick model of the diiodotyrosine molecule as a zwitterion
Names
Preferred IUPAC name (2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.005.539 Edit this at Wikidata
IUPHAR/BPS
MeSH Diiodotyrosine
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1Key: NYPYHUZRZVSYKL-ZETCQYMHSA-N
  • InChI=1/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1Key: NYPYHUZRZVSYKL-ZETCQYMHBZ
SMILES
  • Ic1cc(cc(I)c1O)C(C(=O)O)N
Properties
Chemical formula C9H9I2NO3
Molar mass 432.982 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Diiodotyrosine (DIT) is a precursor in the production of thyroid hormone, and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.

Function

DIT is a modulator of the enzyme thyroid peroxidase (which is involved in the production of thyroid hormones).

Triiodothyronine is formed, when diiodotyrosine is combined with monoiodotyrosine (in the colloid of the thyroid follicle).

Two molecules of DIT combine to make the thyroid hormone thyroxine ('T4' and 'T3').

See also

References

  1. Dème D, Fimiani E, Pommier J, Nunez J (February 1975). "Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase". Eur. J. Biochem. 51 (2): 329–36. doi:10.1111/j.1432-1033.1975.tb03932.x. PMID 1149735.

External links

Thyroid therapy (H03)
Thyroid hormones
Antithyroid preparations
Thyroid peroxidase
inhibitors (thioamide)
Block conversion of
T4 to T3
Sodium-iodide symporter
inhibitor
Other
Thyroid hormone metabolic intermediates
Tyrosine / iodotyrosine
Thyronine / iodothyronine
Thyronamine / iodothyronamine
Iodothyroacetate / iodothyroacetic acid


Stub icon

This article about an organic halide is a stub. You can help Misplaced Pages by expanding it.

Categories:
Diiodotyrosine Add topic