Misplaced Pages

DUSP23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IMG, 4ERC
Identifiers
Aliases	DUSP23, DUSP25, LDP-3, MOSP, VHZ, dual specificity phosphatase 23, LDP3
External IDs	OMIM: 618361; MGI: 1915690; HomoloGene: 32368; GeneCards: DUSP23; OMA:DUSP23 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.2 Start 159,780,932 bp End 159,782,543 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H3 Start 172,458,331 bp End 172,460,529 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left adrenal cortex olfactory zone of nasal mucosa right lobe of liver right adrenal gland minor salivary glands right adrenal cortex mucosa of transverse colon human kidney mucosa of esophagus tendon of biceps brachii Top expressed in muscle of thigh skeletal muscle tissue right kidney triceps brachii muscle quadriceps femoris muscle interventricular septum sternocleidomastoid muscle vastus lateralis muscle medial head of gastrocnemius muscle zygote More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine phosphatase activity protein serine/threonine phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein binding phosphatase activity protein tyrosine/serine/threonine phosphatase activity Cellular component cytoplasm cytosol nucleus nucleoplasm Biological process protein dephosphorylation dephosphorylation peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54935 68440 Ensembl ENSG00000158716 ENSMUSG00000026544 UniProt Q9BVJ7 Q6NT99 RefSeq (mRNA) NM_017823 NM_001319658 NM_001319659 NM_026725 RefSeq (protein) NP_001306587 NP_001306588 NP_060293 NP_081001 Location (UCSC) Chr 1: 159.78 – 159.78 Mb Chr 1: 172.46 – 172.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase 23, also known as low molecular mass dual specificity phosphatase 3 (LDP-3), is an enzyme (EC 3.1.3.16 and EC 3.1.3.48) that in humans is encoded by the DUSP23 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000158716 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026544 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: dual specificity phosphatase 23".
6. Wu Q, Li Y, Gu S, Li N, Zheng D, Li D, Zheng Z, Ji C, Xie Y, Mao Y (August 2004). "Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain". Int. J. Biochem. Cell Biol. 36 (8): 1542–53. doi:10.1016/j.biocel.2003.12.014. PMID 15147733.

Further reading

• Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Liu CY, Wu MC, Chen F, et al. (2010). "A Large-scale genetic association study of esophageal adenocarcinoma risk". Carcinogenesis. 31 (7): 1259–63. doi:10.1093/carcin/bgq092. PMC 2893800. PMID 20453000.
• Alonso A, Burkhalter S, Sasin J, et al. (2004). "The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ". J. Biol. Chem. 279 (34): 35768–74. doi:10.1074/jbc.M403412200. PMID 15201283.
• Takagaki K, Satoh T, Tanuma N, et al. (2004). "Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38". Biochem. J. 383 (Pt. 3): 447–55. doi:10.1042/BJ20040498. PMC 1133737. PMID 15281913.
• Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Tang JP, Tan CP, Li J, et al. (2010). "VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers". Mol. Cancer. 9: 128. doi:10.1186/1476-4598-9-128. PMC 2893100. PMID 20509867.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9BVJ7 (Human Dual specificity protein phosphatase 23 (DUSP23)) at the PDBe-KB.

• Biology

• Genes on human chromosome 1
• EC 3.1.3