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All 18 UCI WorldTeams and five UCI ProTeams made up the 23 teams that participated in the race. All but five teams entered a full squad of seven riders; Bora–Hansgrohe, EF Education–EasyPost, Israel–Premier Tech, Lotto–Soudal, and Quick-Step Alpha Vinyl Team entered six riders each. With one late non-starter, AG2R Citroën Team was also reduced to six riders. In total, 155 riders started the race, of which only 54 finished; there were 25 riders who did not finish the last stage, while a further 39 riders finished over the time limit on the final stage.
On stage 2, Geraint Thomas, who was fourth in the points classification, wore the green jersey, because first-placed Primož Roglič wore the yellow jersey as the leader of the general classification, second-placed Remco Evenepoel wore the polka-dot jersey as the leader of the mountains classification, and third-placed Rémi Cavagna wore the French national champion's jersey as the defending French national road race champion.
On stage 2, Ben Tulett, who was second in the young rider classification, wore the blue jersey, because first-placed Remco Evenepoel wore the polka-dot jersey as the leader of the mountains classification.
On stage 3, Adam Yates, who was fourth in the points classification, wore the green jersey, because first-placed Primož Roglič wore the yellow jersey as the leader of the general classification, second-placed Remco Evenepoel wore the blue jersey as the leader of the young rider classification, and third-placed Julian Alaphilippe wore the world champion's jersey as the defending world road race champion.
On stage 6, Felix Gall, who was second in the young rider classification, wore the blue jersey, because first-placed Remco Evenepoel wore the yellow jersey as the leader of the general classification.
Final classification standings
Legend
Denotes the winner of the general classification
Denotes the winner of the young rider classification
Denotes the winner of the points classification
Denotes the winner of the team classification
Denotes the winner of the mountains classification
As of 1 March 2022, the UCI announced that cyclists from Russia and Belarus would no longer compete under the name or flag of those respective countries due to the Russian invasion of Ukraine.
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