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Methylscopolamine bromide: Difference between revisions

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Revision as of 10:07, 29 July 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,294 edits Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: ChEMBL.← Previous edit Revision as of 10:18, 29 July 2011 edit undoCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'KEGG_Ref') per Chem/Drugbox validation (report errors or [[user talk:CheMoBotNext edit →
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{{Merge|Methylscopolamine|date=October 2009}} {{Merge|Methylscopolamine|date=October 2009}}
{{Drugbox {{Drugbox
⚫ | verifiedrevid = 442016426
| Verifiedfields = changed
⚫ | verifiedrevid = 402390676
| IUPAC_name = (1''R'',2''S'',4''R'',5''S'',7''R'')-{oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclononane | IUPAC_name = (1''R'',2''S'',4''R'',5''S'',7''R'')-{oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclononane
| image = Methscopolamine.png | image = Methscopolamine.png
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 21106347 | ChemSpiderID = 21106347
| ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 376897 | ChEMBL = 376897
| UNII_Ref = {{fdacite|correct|FDA}} | UNII_Ref = {{fdacite|correct|FDA}}

Revision as of 10:18, 29 July 2011

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Find sources: "Methylscopolamine bromide" – news · newspapers · books · scholar · JSTOR (December 2009) (Learn how and when to remove this message)
It has been suggested that this article be merged with Methylscopolamine. (Discuss) Proposed since October 2009.
Pharmaceutical compound
Methylscopolamine bromide
Clinical data
ATC code
  • none
Pharmacokinetic data
Elimination half-life3 - 4hr
Identifiers
IUPAC name
  • (1R,2S,4R,5S,7R)-{oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclononane
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.005.314 Edit this at Wikidata
Chemical and physical data
FormulaC18H24NO4
Molar mass318.388 g/mol g·mol
3D model (JSmol)
SMILES
  • OC(c1ccccc1)C(=O)O2C3(C)(C)(C2)4O34
InChI
  • InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/m1/s1
  • Key:LZCOQTDXKCNBEE-IKIFYQGPSA-N
  (verify)

Methscopolamine, usually provided as a bromide salt (Pamine), is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion. With the advent of proton pump inhibitors and antihistamine medications it is rarely used for this anymore. It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold,irritable bowel syndrome and allergy medications (Extendryl, AlleRx, Rescon).

Methscopolamine, a methylated derivative of scopolamine, is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine. Its mechanism of action involves blocking the muscarinic acetylcholine receptors.


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